PrinciplesofCNSDrugDevelopment

Thistitleactsasaprimer,givingstudentsandnewcomerstothefieldanopportunitytolearnaboutthebreadthoftheCNSdrugdiscovery.ThebookoutlinesthecoreprocessesindrugdiscoveryanddevelopmentforCNSdisorders,fromevaluatingdrugsfordesirableefficacy,safetyandpharmacokineticfeaturesinpreclinical(usinginvitroandinvivomodels)andclinicalexperimentationtoidentifyingfuturedrugtargets.Containingup-to-dateexperimentalevidenceanddetailingthemainimpedimentsinthepipelineofCNSdrugdiscoveryanddevelopment,thisisakeyreferenceforthoseinvolvedinallstagesofCNSdrugdiscovery.KeyFeatures:DiscussesindetailthekeystagesofCNSdrugdiscovery,outliningtheparticularrequirementsandobstaclesforCNSdrugsAddressessafetyconcernsandfuturedrugtargetsProvidessuccinctbackgroundinformationaboutthemajorCNSdiseasesExamplesofspecificdrugsareusedthroughouttodescribethedevelopmentofanewdrugfromconceptiontoclinicaluseandpost-marketsurveillancePrimaryreasonsfordrugfailurearegivenforeachstage