ElementsofComputationalSystemsBiology

Groundbreaking,long-rangingresearchinthisemergentfieldthatenablessolutionstocomplexbiologicalproblemsComputationalsystemsbiologyisanemergingdisciplinethatisevolvingquicklyduetorecentadvancesinbiologysuchasgenomesequencing,high-throughputtechnologies,andtherecentdevelopmentofsophisticatedcomputationalmethodologies.ElementsofComputationalSystemsBiologyisacomprehensivereferencecoveringthecomputationalframeworksandtechniquesneededtohelpresearchscientistsandprofessionalsincomputerscience,biology,chemistry,pharmaceuticalscience,andphysicssolvecomplexbiologicalproblems.Writtenbyleadingexpertsinthefield,thispracticalresourcegivesdetaileddescriptionsofcoresubjects,includingbiologicalnetworkmodeling,analysis,andinference;presentsameasuredintroductiontofoundationaltopicslikegenomics;anddescribesstate-of-the-artsoftwaretoolsforsystemsbiology.OffersacoordinatedintegratedsystemsviewofdefiningandapplyingcomputationalandmathematicaltoolsandmethodstosolvingproblemsinsystemsbiologyChaptersprovideamultidisciplinaryapproachandrangefromanalysis,modeling,prediction,reasoning,inference,andexplorationofbiologicalsystemstotheimplicationsofcomputationalsystemsbiologyondrugdesignandmedicineHelpsreducethegapbetweenmathematicsandbiologybypresentingchaptersonmathematicalmodelsofbiologicalsystemsEstablishessolutionsincomputerscience,biology,chemistry,andphysicsbypresentinganin-depthdescriptionofcomputationalmethodologiesforsystemsbiologyElementsofComputationalSystemsBiologyisintendedforacademic/industryresearchersandscientistsincomputerscience,biology,mathematics,chemistry,physics,biotechnology,andpharmaceuticalscience.Itisalsoaccessibletoundergraduateandgraduatestudentsinmachinelearning,datamining,bioinformatics,computationalbiology,andsystemsbiologycourses.