PHARMACEUTICALDATAMINING:APPROACHESANDAPPLICATIONSFORDRUGDISCOVERY

作者 Konstantin V. Balakin著Sean Ekins编
出版社 Wiley
出版时间 2009年12月
ISBN 9780470196083
定价 1067.90

内容简介

LeadingexpertsillustratehowsophisticatedcomputationaldataminingtechniquescanimpactcontemporarydrugdiscoveryanddevelopmentIntheeraofpost-genomicdrugdevelopment,extractingandapplyingknowledgefromchemical,biological,andclinicaldataisoneofthegreatestchallengesfacingthepharmaceuticalindustry.PharmaceuticalDataMiningbringstogethercontributionsfromleadingacademicandindustrialscientists,whoaddressboththeimplementationofnewdataminingtechnologiesandapplicationissuesintheindustry.Thisaccessible,comprehensivecollectiondiscussesimportanttheoreticalandpracticalaspectsofpharmaceuticaldatamining,focusingondiverseapproachesfordrugdiscovery--includingchemogenomics,toxicogenomics,andindividualdrugresponseprediction.Thefivemainsectionsofthisvolumecover:Ageneraloverviewofthediscipline,fromitsfoundationstocontemporaryindustrialapplicationsChemoinformatics-basedapplicationsBioinformatics-basedapplicationsDataminingmethodsinclinicaldevelopmentDataminingalgorithms,technologies,andsoftwaretools,withemphasisonadvancedalgorithmsandsoftwarethatarecurrentlyusedintheindustryorrepresentpromisingapproachesInoneconcentratedreference,PharmaceuticalDataMiningrevealstheroleandpossibilitiesofthesesophisticatedtechniquesincontemporarydrugdiscoveryanddevelopment.Itisidealforgraduate-levelcoursescoveringpharmaceuticalscience,computationalchemistry,andbioinformatics.Inaddition,itprovidesinsighttopharmaceuticalscientists,principalinvestigators,principalscientists,researchdirectors,andallscientistsworkinginthefieldofdrugdiscoveryanddevelopmentandassociatedindustries.

作者简介

KonstantinV.BalakinisHeadoftheLaboratoryofInformationTechnologyinMedicinalChemistryattheInstituteofPhysiologicallyActiveCompoundsattheRussianAcademyofSciences.HeisalsoDirectorofthescientificconsortium"Orchemed"(OrganicChemistryandMedicine),whichcurrentlyincludes11Russianacademicinstitutesworkinginthefieldoforganic,medicinalandbiologicalchemistry,anddrugdiscovery.Previously,hewasHeadoftheComputationalChemistryDepartmentatChemDiv,Inc.?Dr.Balakin?istheauthororcoauthorofmorethan90peerreviewedresearcharticles,reviews,andbookchapters.HeistheprincipaldeveloperoftheSmartMiningandInformaGenesissoftwaretools,whicharespecialprogramsforpharmaceuticalmultivariatedatamining.

丛书

WileySeriesonTechnologiesforthePharmaceuticalIndustry

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