LC/MSApplicationsinDrugDevelopment(Wiley-InterscienceSeriesonMassSpectrometry)

Breakthroughsincombinatorialchemistryandmolecularbiology,aswellasanoverallindustrytrendtowardaccelerateddevelopment,meantherateofsamplegenerationnowfarexceedstherateofsampleanalysisinthepursuitofproducingnewandbetterpharmaceuticals.LC/MSisananalyticaltoolthathelpstheresearcheridentifythemostpromisingsampleearlyintheselectionprocess,effectivelycreatingashortcuttofindingnewdrugs.ThisbookisthefirsttodescribeLC/MSapplicationswithinthecontextofdrugdevelopment,includingthediscovery,preclinical,clinical,andmanufacturingphases.Inadditiontothethoroughtechnicalanalysisofthistool,LC/MSApplicationsinDrugDevelopmentprovidesperspectiveonthesignificantchangesinstrategiesforpharmaceuticalanalysis.Aprocessoverviewofdrugdevelopmentfromananalyticalpointofviewisprovidedalongwithessentialdatarequiredtosuccessfullybringadrugtomarket.TheincorporationofLC/MSisillustratedfromtargettoproduct.Chapterspertainingtothediscoveryprocessitselfinclude:ProteomicsGlycoproteinMappingNaturalProductsDereplicationLeadIdentificationScreeningOpen-AccessLC/MSInVitroDrugScreeningWrittenforboththeanalyticalchemistwhousesLC/MSapplicationsandthepharmaceuticalscientistwhoworkswiththedrugstheyproduce,LC/MSApplicationsinDrugDevelopmentisthepremierreferenceonthesubject.