SelectionBiasandCovariateImbalancesinRandomizedClinicalTrials

Selectionbiascan,anddoes,occur,eveninrandomizedclinicaltrials.Stepsneedtobetakeninordertoensurethatthisdoesnotcompromisetheintegrityofclinicaltrials;hence“SelectionBiasandCovariateImbalancesinRandomizedClinicalTrials”offersacomprehensivetreatmentofthesubjectandthemethodologyinvolved.Thisbook:Providesanoverviewofthehierarchyofstudydesigns,andjustifiesthepositionofrandomisedtrialsatthetopofthishierarchy.Discussesthestrengthsanddefectsofrandomisation,andprovidesrealevidencetojustifyconcernregardingitsdefects.Outlaysthedamagingconsequencesthatselectionbiascauseswhenitdoesoccur.Considerscoursesofactionthatcanbetakentomanage/containtheproblem.Presentsmethodsthatcanbeusedtodetectselectionbiasinrandomisedtrials,andmethodstocorrectforselectionbias.Concludesbyprovidingacomprehensiveplanformanagingbaselineimbalancesandselectionbiasinrandomisedtrials,andproposingopenproblemsforfutureresearch.Illustratedwithcasestudies,thisbookintroducesgroundbreakingideasandresearchthatwillbeinvaluabletoresearchersandpractitionerswhodesignandanalyseclinicaltrials.Itwillalsobeofinteresttograduatestudentswithinthefieldofbiostatistics.