SYSTEMSBIOLOGYINDRUGDISCOVERYANDDEVELOPMENT

ThefirstbooktofocusoncomprehensivesystemsbiologyasappliedtodrugdiscoveryanddevelopmentDrawingonreal-lifeexamples,SystemsBiologyinDrugDiscoveryandDevelopmentpresentspracticalapplicationsofsystemsbiologytothemultiplephasesofdrugdiscoveryanddevelopment.Thisbookexplainshowtheintegrationofknowledgefrommultiplesources,andthemodelsthatbestrepresentthatintegration,informthedrugresearchprocessesthataremostrelevanttothepharmaceuticalandbiotechnologyindustries.Thefirstbooktofocusoncomprehensivesystemsbiologyanditsapplicationsindrugdiscoveryanddevelopment,itofferscomprehensiveandmultidisciplinarycoverageofallphasesofdiscoveryanddesign,includingtargetidentificationandvalidation,leadidentificationandoptimization,andclinicaltrialdesignandexecution,aswellasthecomplementarysystemsapproachesthatmaketheseprocessesmoreefficient.Italsoprovidesmodelsforapplyingsystemsbiologytopharmacokinetics,pharmacodynamics,andcandidatebiomarkeridentification.Introducingandexplainingkeymethodsandtechnicalapproachestotheuseofcomprehensivesystemsbiologyondrugdevelopment,thebookaddressesthechallengescurrentlyfacingthepharmaceuticalindustry.Asaresult,itisessentialreadingforpharmaceuticalandbiotechscientists,pharmacologists,computationalmodelers,bioinformaticians,andgraduatestudentsinsystemsbiology,pharmaceuticalscience,andotherrelatedfields.