CombinatorialStrategiesinBiologyandChemistry

Combinatorialchemistryhastakenthepharmaceuticalindustrybystormoverthepasttentofifteenyears.Therehasbeenamassiveinvestmentinautomationbypharmaceuticalcompaniesandademandforgraduates/PhDswithexperienceandknowledgeofcombinatorialchemistry.Thesedaystheacademiceducationofchemistsandbiologistsisgraduallyconverging,sothoseenteringthepharmaceuticalindustryneedtobenotonlychemistrygraduatesbutalsobiologistsapplyingtheirbiologicalknowledgetochemistry.Manychemists,however,stillrequireexperienceinbiologicalmethodsandsimilarlybiologistshavenotyetrealizedthepowerofchemicalmethods.Thisbookwillthereforehelpeasethetransitionfrombiologyintochemistryandviceversa,forthoseworkinginthecombinatorialchemistryfield.Becausecombinatorialchemistryevolvedfromtherequirementsofthebiologyfield,theauthorshavewrittenthisbookwithbothbiologistsandchemistsinmind.Combinatorialchemistryisanewandhighlyinfluentialareaofmodernsyntheticchemistrybasedonefficient,parallelsynthesisofmolecules,asopposedtotheuseofseveralsyntheticsteps,toproducemanysetsofcompoundsforbiologicalevaluation.Thetechniquesusedinthisareaarekeytothediscoveryofnewdrugcompoundsinthepharmaceuticalandagrochemicalindustries.CombinatorialMethodsinChemistryandBiologydescribestheorigins,basicsandtechniquesusedbothincombinatorialchemistryandmolecularbiology.Keyfeatures:Firstbooktocovercombinatorialmethodsinbothchemistryandbiology-idealforthosewitheitherachemicalorbiologicalbackground.Introductorytext-idealfornewcomerstothefield.Coversawideswatheoftechniquesandtopics-providingbeginnerswithacompleteoverviewofthefield.Containschaptersonsupportingmaterialandlinkers,twoimportantareasinthefield.Up-to-dateandtopical.Thisvolumewillbeofkeyinteresttotechnicians/scientistsworkinginthepharmaceuticalindustrywithbackgroundsineitherbiologyorchemistry.Itwillalsobeinvaluabletostudents-postgraduatesstudyingchemistryandmolecularbiologyorthosechemistry/molecularbiologyundergraduatesatuniversitieswherecombinatorialchemistryistaughtasamodule.