内容简介
EditedbyleadingexpertsintheEUandtheUS,thisbookprovidesauniquecoverageofnoveltechnologyapproachesforthedetectionofhighlyrelatedvariantsofdangerousagentsandnoveltherapyoptions.Amust-haveforallprofessionalsdealingwithBSL3and/orBSL4agents
作者简介
Prof.J.Stulik,MD,PhDisaheadoftheInstituteofMolecularPathology,FacultyofMilitaryHealthSciences.ThisinstituteistheonlyfacilityinCzechRepublicengagedinbiodefenseresearch.TheresearchactivityisfocusedonintracellularpathogenFrancisellatularensisthatisclassifiedasaclassAagentbytheU.S.government.Theinstituteexploitsthemethodsoffunctionalgenomicsandsystembiologyfortheidentificationofbothmicrobialandhostmoleculesinvolvedinhost-pathogeninteraction.Theresultsofthisstudyareimportantfordevelopmentofnewprophylacticandtherapeuticagentsagainsttularemia.RudolfToman,PhD,DScisheadoftheLaboratoryforDiagnosisandPreventionofRickettsialandChlamydialInfectionsattheInstituteofVirologyoftheSlovakAcademyofSciencesinBratislava,Slovakia.Thelaboratoryisengagedinmicrobiologicalandglycomics/proteomicsstudiesofBSL3bacteriathatpotentiallycanbeusedasbiologicalwarfareagents.ThespecialemphasisisputontheintracellularpathogenCoxiellaburnetiithatisclassfiedasacategoryBbiologicalwarfareagentbytheUSauthorities.Structure/functionrelationshipstudiesofthesurfacemacromolecules(lipopolysaccharidesandproteins)ofC.burnetii,RickettsiaeandChlamydiaeareperformedtogetherwithcharacterizationoftheirimmunodominantepitopeswiththeaimtodevelopnewdiagnosticandprophylacticagentsagainstthesehighlyinfectiouspathogens.PatrickButayeisaveterinaryresearcherattheVeterinaryandAgrochemicalResearchCenterinBrusselswithafocusonantimicrobialresistanceinbacteriafromanimalorigin.RobertG.UlrichischiefoftheDepartmentofImmunologyandheadoftheLaboratoryofMolecularImmunologyattheUnitedStatesArmyMedicalResearchInstituteofInfectiousDiseases(USAMRIID).USAMRIIDistheprimaryU.S.DepartmentofDefenselaboratorydedicatedtoresearchinbiodefenseandinfectiousdiseases.HereceivedaPh.D.inMicrobiologyandImmunologyfromBaylorCollegeofMedicine.Hislaboratoryusesmicroarraysandotherproteomictoolstostudyvirulencefactors,proteininteractionnetworksandhostresponsestoinfectiousdiseases.Thisworkhasresultedinthedevelopmentofmanypatenteddiagnosticassaysandvaccines.
