AbdominalAorticAneurysm:Genetics,Pathophysiology,andMolecularBiology

Anincreaseinincidenceofabdominalaorticaneurysmispredictedasanextensionoftheadvancingageofourpopulation.Novelstrategiesfortreatmentandpreventionneedtobeconsidered.Interdisciplinaryapproachestothisdiseasewillaidinpreventionandtreatment.Thisvolumewillintegratenewinsightsintotheetiologyandpathologyofaneurismaldisease,includingphysiologicandgeneticcauses.Severaleducationalobjectiveshavebeenmetinthisvolume.Thecontributorsassessthebenefitsofriskofruptureassessmentatdifferentagesandthresholdsofabdominalaorticaneurysminthecontextofepidemiologicstudies,examinetheuseofanimalmodelsinthestudyofabdominalaorticaneurysmanditsunderlyingpathobiology,andintegratedataonsusceptibilityandgeneticcausesofabdominalaorticaneurysms.Theincreaseinabdominalaorticaneurysms(AAA)isviewedfromtheperspectiveofepidemiology,andinitiativestopreventdeathfromrupturearediscussed.Animalmodelsandtheirrelevancetopathophysiologyandpreventionarealsopresented,andtheinterventionalpharmacologyisalsoconsideredfromtheperspectiveofenzymology.Inaddition,chapterscoveringthebiologicalaspectsoftheendovasculardevicesusedtorepairabdominalaorticaneurysmandthemolecularbiologyandimmunologyinabdominalaorticaneurysmareincluded.NOTE:Annalsvolumesareavailableforsaleasindividualbooksorasajournal.Forinformationoninstitutionaljournalsubscriptions,pleasevisitwww.blackwellpublishing.com/nyas.ACADEMYMEMBERS:PleasecontacttheNewYorkAcademyofSciencesdirectlytoplaceyourorder(www.nyas.org).MembersoftheNewYorkAcademyofSciencereceivefull-textaccesstotheAnnalsonlineanddiscountsonprintvolumes.Pleasevisithttp://www.nyas.org/MemberCenter/Join.aspxformoreinformationaboutbecomingamember