DrugDiscoveryforNervousSystemDiseases
- 作者
- 出版社 Wiley-Liss
- 出版时间 2004年11月
- ISBN 9780471465638
- 定价 1590.90
内容简介
Theneuroscienceshavebeenanespeciallydifficultfieldfordrugdiscovery.Becauseofthehugecomplexityofthenervoussystemandpoorunderstandingofmostpsychiatricandneurologicaldiseases,mostdrugscurrentlyavailablearetheresultofchanceobservationsratherthanatrulycomprehensiveapproach.However,thissituationhasbeguntochange.Enormousprogressinmolecularbiologyhasyieldedbreakthroughdiscoveriesofthecausesofnervoussystemdiseases,openingthedoorforbetter–targetedandentirelynoveltherapies.Reflectingtheserecentadvances,DrugDiscoveryforNervousSystemDiseasespresentsthelatesttechniquesandapproachesfordrugdiscovery,organizingthemaccordingtodiseasesratherthanclassesofdrugsordrugtargets,aspastbookshavedone.Writtenwithoptimisticanticipationofgreatprogressstilltocome,thistextprovidesbothaguidetopresentrealitiesandalooktofuturepossibilitiesinthisburgeoningfield.CoverageinDrugDiscoveryforNervousSystemDiseasesincludes:?Fundamentalsofdrugdiscovery–receptors,targetselection,anddrugdevelopment?Schizophrenia?Depression?Anxietydisorders?Alzheimer′sdisease?Parkinson′sdisease?Ischemicstroke,brain,andspinalcordinjury?Otherneurodegenerativediseases?Sleepdisorders?Epilepsy?PainThispracticalhandbookfeaturesauniformpresentationforeachchapter,withabriefdescriptionofexistingdrugsleadingtorecentmolecularbiologicalandgeneticfindings,translationalresearchandtheinterfacetoclinicaltrials,andfinallyanoutlookonfuturedrugtargets.Richillustrations–schematicdiagramsandtables–provideadynamicvisualexperiencethroughoutthetext.Auniqueandup–to–dateguidetoafieldcurrentlyundergoingamajorgrowthspurt,DrugDiscoveryforNervousSystemDiseasesoffersbothpractitionersandadvancedstudentsanunparalleledresource.
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