内容简介
Thisbookprovidesanoverviewofdifferentproteinkinases–structure,function,regulation,andtheirroleincancer.Itcombineskinasebiologywithchemistryandpharmacologyapplicationsfordiscoveryanddevelopmentofcancerdrugs.Thetextalsodescribesexistingandemergingkinaseinhibitors,focusingmostlyonsmallmoleculesbutalsoalternativeapproachesliketherapeuticantibodies.Providesanimportantresourcethathelpspharmaceuticalresearchersunderstandandworkinthisdynamicareaofcancerdrugresearch.
作者简介
DAVIDJ.MATTHEWSisExecutiveDirectorofOncologyDiscoveryatExelixis,whereheisresponsibleforcancerdrugdiscovery.Formorethanfifteenyears,Dr.Matthewshasbeeninvolvedindrugdiscoveryprojectsinindustry,withparticularfocusonsmallmoleculeinhibitors.Hehastwentyscientificpublicationsandmultiplepatentstohiscredit.MARYE.GERRITSENisVicePresidentofMolecularandCellularPharmacologyatExelixis,wheresheisinchargeofcell-basedscreeninginpreclinicalresearchandofbiomarkerstudiesforclinicaldevelopmentcompoundsinPhaseIandIIstudies.HerpriorindustryexperienceincludespositionsatGenentech,BayerandMillenniumPharmaceuticals.Shehasauthoredmorethanonehundredpeer-reviewedarticlesandtwenty-sixbookchaptersandisaninventoronforty-twoissuedpatents.
