Process Development: Fine Chemicals from Grams to Kilograms

Processdevelopmentbridgesthegapbetweenthelaboratorysynthesisofanorganiccompoundanditsindustrialmanufactureonalargescale.ThisconciseandreadabletextusesrealexamplesandcasehistoriesfromICI/ZenecaPharmaceuticalstoshowtheproblemswhichmaybeencounteredinscalingupchemicalsynthesis,andthewaystheseproblemsmaybeovercome.Itshowshowitispossibletosynthesizemulti-kilogramquantitiesofaneworganiccompoundwhichhasbeenmadeinthelaboratoryonlyinthemilligramscale.Awiderangeofaliphatic,aromatic,andheterocycliccompoundsiscovered.Thisbookwillbeinvaluablebothtotheresearchchemistinvolvedinthedevelopmentphaseofnovelcompounds,andtheadvancedundergraduateinterestedinthefinechemicalsindustry.