内容简介
Theclassictextbookinmolecularbiology,updatedwithnewchapters,newinformation,andnewmedia.Completelyup-to-datewiththelatestresearchadvances,theSixthEditionofJamesD.Watson’sclassictext,MolecularBiologyoftheGeneretainsthed
作者简介
JamesD.WatsonwasDirectorofColdSpringHarborLaboratoryfrom1968to1993,Presidentfrom1994to2003,andisnowitsChancellor.HespenthisundergraduateyearsattheUniversityofChicagoandreceivedhisPh.D.in1950fromIndianaUniversity.Between1950and1953,hedidpostdoctoralresearchinCopenhagenandCambridge,England.WhileatCambridge,hebeganthecollaborationthatresultedintheelucidationofthedouble-helicalstructureofDNAin1953.(Forthisdiscovery,Watson,FrancisCrick,andMauriceWilkinswereawardedtheNobelPrizein1962.)Laterin1953,hewenttotheCaliforniaInstituteofTechnology.HemovedtoHarvardin1955,wherehetaughtanddidresearchonRNAsynthesisandproteinsynthesisuntil1976.HewasthefirstDirectoroftheNationalCenterforGenomeResearchoftheNationalInstitutesofHealthfrom1989to1992.Dr.Watsonwassoleauthorofthefirst,second,andthirdeditionsofMolecularBiologyoftheGene,andaco-authorofthefourthandfiftheditions.Thesewerepublishedin1965,1970,1976,1987,and2003,respectively.Heisalsoaco-authoroftwoothertextbooks:MolecularBiologyoftheCellandRecombinantDNA.TaniaA.BakeristheWhiteheadProfessorofBiologyattheMassachusettsInstituteofTechnologyandanInvestigatoroftheHowardHughesMedicalInstitute.ShereceivedaB.S.inbiochemistryfromtheUniversityofWisconsin,Madison,andaPh.D.inbiochemistryfromStanfordUniversityin1988.HergraduateresearchwascarriedoutinthelaboratoryofProfessorArthurKornbergandfocusedonmechanismsofinitiationofDNAreplication.ShedidpostdoctoralresearchinthelaboratoryofDr.KiyoshiMizuuchiattheNationalInstitutesofHealth,studyingthemechanismandregulationofDNAtransposition.Hercurrentresearchexploresmechanismsandregulationofgeneticrecombination,enzyme-catalyzedproteinunfolding,andATP-dependentproteindegradation.ProfessorBakerreceivedthe2001EliLillyResearchAwardfromtheAmericanSocietyofMicrobiologyandthe2000MITSchoolofScienceTeachingPrizeforUndergraduateEducationandwaselectedasafellowoftheAmericanAcademyofArtsandSciencesin2004.Sheisco-author(withArthurKornberg)ofthebookDNAReplication,SecondEdition.StephenP.BellisaProfessorofBiologyattheMassachusettsInstituteofTechnologyandanInvestigatoroftheHowardHughesMedicalInstitute.HereceivedB.A.degreesfromtheDepartmentofBiochemistry,MolecularBiology,andCellBiologyandtheIntegratedSciencesProgramatNorthwesternUniversityandaPh.D.inbiochemistryattheUniversityofCalifornia,Berkeleyin1991.HisgraduateresearchwascarriedoutinthelaboratoryofDr.RobertTjianandfocusedoneukaryotictranscription.HedidpostdoctoralresearchinthelaboratoryofDr.BruceStillmanatColdSpringHarborLaboratory,workingontheinitiationofeukaryoticDNAreplication.Hiscurrentresearchfocusesonthemechanismscontrollingtheduplicationofeukaryoticchromosomes.ProfessorBellreceivedthe2001ASBMB–ScheringPloughScientificAchievementAward,the1998EverettMooreBakerMemorialAwardforExcellenceinUndergraduateTeachingatMITandthe2006MITSchoolofScienceTeachingAward.AlexanderA.F.GannisEditorialDirectorofColdSpringHarborLaboratoryPress,andafacultymemberoftheWatsonSchoolofBiologicalSciencesatColdSpringHarborLaboratory.HereceivedhisB.ScinmicrobiologyfromUniversityCollegeLondonandaPh.D.inmolecularbiologyfromTheUniversityofEdinburghin1989.HisgraduateresearchwascarriedoutinthelaboratoryofNoreenMurrayandfocusedonDNArecognitionbyrestrictionenzymes.HedidpostdoctoralresearchinthelaboratoryofMarkPtashneatHarvard,workingontranscriptionalregulation,andthatofJeremyBrockesattheLudwigInstituteofCancerResearchatUniversityCollegeLondon,whereheworkedonnewtlimbregeneration.HewasaLectureratLancasterUniversity,U.K.,from1996to1999,beforemovingtoColdSpringHarborLaboratory.Heisco-author(withMarkPtashne)ofthebookGenes&Signals(2002).MichaelLevineisaProfessorofMolecularandCellBiologyattheUniversityofCalifornia,Berkeley,andisalsoCo-DirectoroftheCenterforIntegrativeGenomics.HereceivedhisB.A.fromtheDepartmentofGeneticsatUniversityofCalifornia,Berkeley,andhisPh.D.withAlanGarenintheDepartmentofMolecularBiophysicsandBiochemistryfromYaleUniversityin1981.AsapostdoctoralfellowwithWalterGehringandGerryRubinfrom1982-1984,hestudiedthemoleculargeneticsofDrosophiladevelopment.ProfessorLevine'sresearchgroupcurrentlystudiesthegenenetworksresponsibleforthegastrulationoftheDrosophilaandCiona(seasquirt)embryos.HeholdstheF.WilliamsChairinGeneticsandDevelopmentatUniversityofCalifornia,Berkeley.HewasawardedtheMonsantoPrizeinMolecularBiologyfromtheNationalAcademyofSciencesin1996,andwaselectedtotheAmericanAcademyofArtsandSciencesin1996andtheNationalAcademyofSciencesin1998.RichardM.LosickistheMariaMoorsCabotProfessorofBiology,aHarvardCollegeProfessor,andaHowardHughesMedicalInstituteProfessorintheFacultyofArts&SciencesatHarvardUniversity.HereceivedhisA.B.inchemistryatPrincetonUniversityandhisPh.D.inbiochemistryattheMassachusettsInstituteofTechnology.Uponcompletionofhisgraduatework,ProfessorLosickwasnamedaJuniorFellowoftheHarvardSocietyofFellowswhenhebeganhisstudiesonRNApolymeraseandtheregulationofgenetranscriptioninbacteria.ProfessorLosickisapastChairmanoftheDepartmentsofCellularandDevelopmentalBiologyandMolecularandCellularBiologyatHarvardUniversity.HereceivedtheCamilleandHenryDreyfussTeacher-ScholarAward,isamemberoftheNationalAcademyofSciences,aFellowoftheAmericanAcademyofArtsandSciences,aFellowoftheAmericanAssociationfortheAdvancementofScience,aFellowoftheAmericanAcademyofMicrobiology,amemberoftheAmericanPhilosophicalSociety,andaformerVisitingScholarofthePhiBetaKappaSociety.ProfessorLosickisthe2007winneroftheSelmanA.WaksmanAwardoftheNationalAcademyofSciences.
