ABCTransportersandMultidrugResistance(WileySeriesinDrugDiscoveryandDevelopment)
- 作者
- 出版社 Wiley
- 出版时间 2009年7月
- ISBN 9780470227343
- 定价 1067.90
内容简介
AcomprehensivereviewofthemostcurrentscientificresearchonABCtransportersandmultidrugresistanceATP-bindingcassettetransportergenes(ABCtransporters)areknowntoplayacrucialroleinthedevelopmentofmultidrugresistance(MDR).MDRistheabilityofpathologiccells,suchastumors,towithstandchemicalsdesignedtotargetanddestroysuchcells.InMDR,patientswhoareonmedicationeventuallydevelopresistancetonotonlythedrugtheyaretaking,buttoseveraldifferenttypesofdrugs.ABCTransportersandMultidrugResistanceoffersanessentialresourceforpharmaceuticalresearcherswhoareworkingtodiscoverdrugstocounteractmultidrugresistanceindiseasessuchascancer.Inonecomprehensivevolume,thisbookcontainsacollectionofthemostcurrentknowledgeontheinvolvementofABCtransportersindrugtransportandresistance.Thiscomprehensivevolumeprovidesanoverviewonthedescriptionofthestructure,thegenome,normaltissueexpression,physiologicalaspect,andmechanismofactionoftheABCprotein.Theexpertcontributorsexploretheexpression,detection,andimplicationsofABCproteinsinhematologicalmalignanciesandsolidtumorsandABCproteinsandpathogenicmicroorganisms.ThisvolumealsoexplainsMDRmodulationthroughinhibitionofABCtransportersandthedesignofinhibitorsandmechanismofaction.Inaddition,thebookoffersessentialinformationonthebiologicalandclinicalaspectofmultidrugresistance.
丛书
WileySeriesinDrugDiscoveryandDevelopment— END —