FluorineinMedicinalChemistryandChemicalBiology
- 作者
- 出版社 Wiley-Blackwell
- 出版时间 2009年5月
- ISBN 9781405167208
- 定价 1652.60
内容简介
Theextraordinarypotentialoffluorine–containingmoleculesinmedicinalchemistryandchemicalbiologyhasbeenrecognizedbyresearchersoutsideofthetraditionalfluorinechemistryfield,andthusanewwaveoffluorinechemistryisrapidlyexpandingitsbiomedicalfrontiers.Withseveralofthebestsellingdrugsintheworldcruciallycontainingfluorineatoms,theincorporationoffluorinetodrugleadshasbecomeanessentialpracticeinbiomedicalresearch,especiallyfordrugdesignanddiscoveryaswellasdevelopment.Focusingontheuniqueandsignificantrolesthatfluorineplaysinmedicinalchemistryandchemicalbiology,thisbookreviewsrecentadvancesandfutureprospectsinthisrapidlydevelopingfield.Topicscoveredinclude:Discoveryanddevelopmentoffluorinecontainingdrugsanddrugcandidates.Newandefficientsyntheticmethodsformedicinalchemistryandtheoptimisationoffluorine–containingdrugcandidates.Structuralandchemicalbiologyoffluorinatedaminoacidsandpeptides.Fluorinelabelsasprobesinmetabolicstudy,proteinengineeringandclinicaldiagnosis.Applicationsof19FNMRspectroscopyinbiomedicalresearch.Anappendixpresentsaninvaluableindexofallfluorine–containingdrugsthathavebeenapprovedbytheUSFoodandDrugAdministration,includinginformationonstructureandpharmaceuticalaction.FluorineinMedicinalChemistryandChemicalBiologywillserveasanexcellentreferencesourceforgraduatestudentsaswellasacademicandindustrialresearcherswhowanttotakeadvantageoffluorineinbiomedicalresearch.
— END —