Bio-Nanoimaging:ProteinMisfolding&Aggregation
- 作者
- 出版社 AcademicPress
- 出版时间 2013年12月
- ISBN 9780123944313
- 定价 1423.50
内容简介
Bio-Nanoimaging:ProteinMisfolding&Aggregationprovidesauniqueintroductiontobothnovelandestablishednanoimagingtechniquesforvisualizationandcharacterizationofmisfoldedandaggregatedproteinspecies.Thebookisdividedintothreesectionscovering:nanotechnologyandnanoimagingtechnology,includingcryoelectronmicroscopyofbeta(2)-microglobulin,studyingamyloidogensisbyFRET;andscanningtunnelingmicroscopyofproteindeposits;polymorphismsofproteinmisfoldedandaggregatedspecies,includingfibrillarpolymorphism,amyloid-likeprotofibrils,andinsulinoligomers;polymorphismsofmisfoldingandaggregationprocesses,includingmultiplepathwaysoflysozymeaggregation,misfoldedintermediateofaPDZdomain,andmicelleformationbyhumanisletamyloidpolypeptide.Proteinmisfoldingandaggregationisafast-growingfrontierinmolecularmedicineandproteinchemistry.Relateddisordersincludecataracts,arthritis,cysticfibrosis,late-onsetdiabetesmellitus,andnumerousneurodegenerativediseaseslikeAlzheimer'sandParkinson's.Nanoimagingtechnologyhasprovedcrucialinunderstandingprotein-misfoldingpathologiesandinpotentialdrugdesignaimedattheinhibitionorreversalofproteinaggregation.Usingthesetechnologies,researcherscanmonitortheaggregationprocess,visualizeproteinaggregatesandanalyzetheirproperties.Itprovidespracticalexamplesofnanoimagingresearchfromleadingmolecularbiology,cellbiology,proteinchemistry,biotechnology,genetics,andpharmaceuticallabs.Itincludesover200colorimagestoillustratethepowerofvariousnanoimagingtechnologies.Itfocusesonnanoimagingtechniquesappliedtoproteinmisfoldingandaggregationinmolecularmedicine.
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