内容简介
Apractice–orientedall–in–oneguidethatprovidesthenecessaryknowledgeforeffectiveprocessdevelopmentinchromatographicbioseparation,bothforpreparative–scaleandforlarge–scaleindustrialapplications.Withitsfocusonprocessdevelopmentandbioseparationtasks,thisistailor–madereadingfortheprofessionalbioengineerinboththebiotechandpharmaceuticalindustries.Followingatried–and–testedconcept,thisguidehasbeendevelopedoverseveralyearsintrainingcoursesforbiotechandchemicalengineersinEuropeandtheU.S.Coveragebeginswithanoverviewofbiomolecularpropertiesandtheirrelationshiptodownstreamprocessing,followedbyadetailedtreatmentofbioprocesschromatography,itsdynamics,themasstransferanddispersioneffectsthatcontrolitsperformance,thecriticaldesignandscale–uprelationships,aswellastherelevantstationaryphasesandequipment.
作者简介
GIORGIOCARTAreceivedhisPhDinChemicalEngineeringfromtheUniversityofDelawarein1984.SincethenhehasbeenaprofessorintheDepartmentofChemicalEngineeringattheUniversityofVirginia,Charlottesville(USA),wherehisresearchfocusesontransportphenomenaandbioseparations.Heregularlyorganizesprofessionalcoursesonvariousaspectsofbioseparations,includingacourseonproteinchromatographydevelopmentandscale-uptogetherwithAloisJungbauer.ALOISJUNGBAUERistheheadofproteintechnologyanddownstreamprocessingattheDepartmentofBiotechnologyoftheUniversityofNaturalResourcesandAppliedLifeSciencesinVienna(Austria).Formorethan20years,ProfessorJungbauerhasworkedinbiochemicalengineering,withafocusonbioseparation,wherehehaspublishedwidelyandholds15patents.Forover10years,hehasorganizedabiennialprofessionalcourseinproteinchromatographyfocusedonmasstransfer,dispersion,andscale-up.