CombinatorialChemistryandMolecularDiversityinDrugDiscovery

COMBINATORIALCHEMISTRYANDMOLECULARDIVERSITYINDRUGDISCOVERYEditedbyEricM.GordonandJamesF.Kerwin,Jr.Increasingpressuretoidentify,optimize,develop,andcommercializenoveldrugsmorerapidlyandmorecost-effectivelyhasledtoanurgentdemandfortechnologiesthatcanreducethetimetomarketfornewproducts.Moleculardiversity,ofbothnaturalandsyntheticmaterials,providesavaluablesourceofcompoundsforidentifyingandoptimizingnewdrugleads.Throughtherapidlyevolvingtechnologyofcombinatorialchemistry,itisnowpossibletoproducelibrariesofsmallmoleculestoscreenfornovelbioactivities.Thispowerfulnewtechnologyhasbeguntohelppharmaceuticalcompaniesfindnewdrugcandidatesquickly,savesignificantdollarsinpreclinicaldevelopmentcosts,andultimatelychangetheirfundamentalapproachtodrugdiscovery.Comprisingtheworkoftheleadingauthoritiesintheareaofmoleculardiversityandcombinatorialchemistry,CombinatorialChemistryandMolecularDiversityinDrugDiscoveryhighlightsthecriticalconceptsandissuesinvolvedinimplementingcombinatorialchemistrytocreatechemicallibraries.Theauthors,industrialandacademicexpertsinthefield,applycombinatorialtechnologiestodrugdiscoveryanddevelopmentandplaceco-evolvingtechnologiesandpracticesinaglobalframework.Includedamongthemanytopics:*Historicalbackground.*Librarystrategyanddesign.*Solid-phasesynthesis.*Smallmolecularlibraries.*Automation,analytical,andcomputationalmethodology.*Biologicaldiversity.*Strategiesforscreeningcombinatoriallibraries.*Combinatorialdrugscreeninganddevelopment.*Combinatorialchemistryinformationmanagement.CombinatorialChemistryandMolecularDiversityinDrugDiscoveryisoneofthefirstcomprehensivebookstocoverthisexplosivearea.Itismustreadingformedicinalchemists,pharmacologists,molecularbiologists,biochemists,enzymologists,anddrugdiscoveryresearchmanagersinindustry,academia,andgovernment.