CriticalContributionsoftheOrbitofrontalCortextoBehavior

Thepasttenyearshavewitnessedintenseresearchonthefunctionoforbitofrontalcortex.Asaresult,theorbitofrontalcortexhasbeenassignedrolesinanumberofhumanbehaviorsandemotions,fromtaskssuchasassessingeconomicvalueandmakingdecisionstotheemotionalstatesofregretanduncertainty.Orbitofrontaldysfunctionhasalsobeenimplicatedinavarietyofhumandiseasestates,includingaddiction,depressionandbipolar,obsessive-compulsive,andattentiondeficitdisorders.Despiteanenormousincreaseinourknowledgeaboutthisregion,westilldonothaveanaccountofthecontributionsthattheorbitofrontalcortexmakesacrossdifferentcircuitstosupporthumanbehavior,nordoweunderstandhowchangesinthisstructureoritsconnectivitymaycontributetodiseasestates.Thisvolumeexploresareasofresearcharecriticaltomovethefieldbeyondacircuit-centricviewoftheorbitofrontalcortextodefinetherolesthisareaplaysinhumanbehaviorandmentalhealth.NOTE:Annalsvolumesareavailableforsaleasindividualbooksorasajournal.Forinformationoninstitutionaljournalsubscriptions,pleasevisithttp://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632.ACADEMYMEMBERS:PleasecontacttheNewYorkAcademyofSciencesdirectlytoplaceyourorder(www.nyas.org).MembersoftheNewYorkAcademyofSciencereceivefull-textaccesstoAnnalsonlineanddiscountsonprintvolumes.Pleasevisithttp://www.nyas.org/MemberCenter/Join.aspxformoreinformationaboutbecomingamember.