Molecular Biology of the Cell：Fifth Edition

FornearlyaquartercenturyMolecularBiologyoftheCellhasbeentheleadingcellbiologytextbook.ThistraditioncontinueswiththenewFifthEdition,whichhasbeencompletelyrevisedandupdatedtodescribeourcurrent,rapidlyadvancingunderstandingofcellbiology.Tolistbutafewexamples,alargeamountofnewmaterialispresentedonepigenetics;stemcells;RNAi;comparativegenomics;thelatestcancertherapies;apoptosis(nowitsownseparatechapter);andcellcyclecontrolandthemechanicsofMphase(nowintegratedintoonechapter).ThehallmarkfeaturesofMolecularBiologyoftheCellhavebeenretained,suchasitsconsistentandcomprehensiveartprogram,clearconceptheadings,andsuccinctsectionsummaries.Additionally,inresponsetoextensivefeedbackfromreaders,theFifthEditionnowincludesseveralnewfeatures.Itisnowmoreportable.Chapters1-20areprintedandChapters21-25,coveringmulticellularsystems,areprovidedaspdffilesonthefreeMediaDVD-ROMwhichaccompaniesthebook.*Andforthefirsttime,MolecularBiologyoftheCellnowcontainsend-of-chapterquestions.Theseproblems,writtenbyJohnWilsonandTimHunt,emphasizeaquantitativeapproachandtheartofreasoningfromexperiments,and-theywillhelpstudentsreviewandextendtheirknowledgederivedfromreadingthetextbook.TheMediaDVD-ROM,whichispackagedwitheverycopyofthebook,containsPowerPoint®presentationswithallofthefigures,tablesandmicrographsfromthetext(availableasJPEGstoo).AlsoincludedistheMediaPlayer,whichplaysover125movies—animations,videos,andmolecularmodels—allwithvoiceovernarration.Anewreader-friendlyfeatureistheintegrationofmediacodesthroughoutthetextthatlinkdirectlytorelevantvideosandanimations.TheMediaDVD-ROMholdsthemulticellularsystemschapters(21-25)ofthetextaswell.Byskillfullyextractingthefundamentalconceptsfromthisenormousandever-growingfield,theauthorstellthestoryofcellbiology,andtherebycreateacoherentframeworkthroughwhichreadersmayapproachandenjoythissubjectthatissocentraltoallofbiology.*ThereisalsoareferenceeditionofMolecularBiologyoftheCell,FifthEdition(ISBN978-0-8153-4111-6)thatcontainsChapters1-25entirelyinprintedformat.AbouttheAuthorBruceAlbertsreceivedhisPh.D.fromHarvardUniversityandisProfessorofBiochemistryandBiophysicsattheUniversityofCalifornia,SanFrancisco.For12years,heservedasPresidentoftheU.S.NationalAcademyofSciences(1993-2005).AlexanderJohnsonreceivedhisPh.D.fromHarvardUniversityandisProfessorofMicrobiologyandImmunologyandDirectoroftheBiochemistry,CellBiology,Genetics,andDevelopmentalBiologyGraduateProgramattheUniversityofCalifornia,SanFrancisco.JulianLewisreceivedhisD.Phil.fromtheUniversityofOxfordandisaPrincipalScientistattheLondonResearchInstituteofCancerResearchUK.MartinRaffreceivedhisM.D.fromMcGillUniversityandisattheMedicalResearchCouncilLaboratoryforMolecularCellBiologyandtheBiologyDepartmentatUniversityCollegeLondon.KeithRobertsreceivedhisPh.D.fromtheUniversityofCambridgeandisEmeritusFellowattheJohnInnesCentre,Norwich.PeterWalterreceivedhisPh.D.fromTheRockefellerUniversityinNewYorkandisProfessorandChairmanoftheDepartmentofBiochemistryandBiophysicsattheUniversityofCalifornia,SanFrancisco,andanInvestigatoroftheHowardHughesMedicalInstitute.