Principles and Methods of Toxicology：FIFTH EDITION

Foundedontheparadoxthatallthingsarepoisonsandthedifferencebetweenpoisonandremedyisquantity,thedeterminationofsafedosageformsthebaseandfocusofmoderntoxicology.Inordertomakeasounddeterminationtheremustbeaworkingknowledgeofthebiologicmechanismsinvolvedandofthemethodsemployedtodefinethesemechanisms.Whilethevastnessofthefieldandtherapidaccumulationofdatamayprecludethepossibilityofabsorbingandretainingmorethanafractionoftheavailableinformation,asolidunderstandingoftheunderlyingprinciplesisessential.Extensivelyrevisedandupdatedwithfournewchaptersandanexpandedglossary,thisfiftheditionoftheclassictext,"PrinciplesandMethodsofToxicology"providescomprehensivecoverageinamanageableandaccessibleformat.Thenewtopicsinclude'toxicopanomics',plantandanimalpoisons,informationresources,andnon-animaltestingalternatives.Emphasizingthecornerstonesoftoxicology-peoplediffer,dosematters,andthingschange,thebookbeginswithareviewofthehistoryoftoxicologyandfollowedbyanexplanationofbasictoxicologicalprinciples,agentsthatcausetoxicity,targetorgantoxicity,andtoxicologicaltestingmethodsincludingmanyofthetestprotocolsrequiredtomeetregulatoryneedsworldwide.Thebookexamineseachmethodorprocedurefromthestandpointoftechniqueandinterpretationofdataanddiscussesproblemsandpitfallsthatmaybeassociatedwitheach.Theadditionofseveralnewauthorsallowforabroaderandmorediversetreatmentoftheever-changingandexpandingfieldoftoxicology.Maintainingthehigh-qualityinformationandorganizationalframeworkthatmadethepreviouseditionssosuccessful,"PrinciplesandMethodsofToxicology,FifthEdition"continuestobeavaluableresourcefortheadvancedpractitioneraswellasthenewdiscipleoftoxicology.