内容简介
StephenHawkingsaysthatthenext21stcenturywillbethecenturyofcomplexityandindeednowSystemsBiologyorMedicinemeansdealingwithcomplexity.Bothgenomeandphysiomehavebeenemergedinstudyingcomplexphysiologicalsystems.Computationalandmathematicalmodellinghasbeenregardedasanefficienttooltoboostunderstandingaboutthelivingsystemsinnormalorpathophysiologicalstates.Thistextbookintroducesthestudentsandresearcherstothemodellingandcomputationalstudyofphysiology(i.e.quantitativephysiology),whichisanincreasinglyimportantbranchofsystemsbiology.Thetopicscoverbasicmethodology,casepracticesandadvancedapplications.Thisbookaimstobuildmultiscalemodelforinvestigatingthefunctioninlivingsystems,or,howorganisms,organsystems,organs,cells,andbiomoleculescarryoutthechemicalorphysicalfunctionsthatexistinalivingsystem.Someofthemodelsrelatedongeneexpression,calciumsignalling,neuralactivity,blooddynamicsandbonemechanicshavebeenaddressed.Thisbookisdevotedtosetaparadigmforquantitativephysiologybyintegratingbiology,mathematics,physicsandinformaticsetc.