内容简介
Wereyoualwayscuriousaboutbiologybutwereafraidtositthroughlonghoursofdensereading?Didyoulikethesubjectwhenyouwereinhighschoolbuthadotherplansafteryougraduated?NowyoucanexplorethehumangenomeandanalyzeDNAwithouteverleavingyourdesktop!BioinformaticsForDummiesispackedwithvaluableinformationthatintroducesyoutothisexcitingnewdiscipline.Thiseasy-to-followguideleadsyoustepbystepthrougheverybioinformaticstaskthatcanbedoneovertheInternet.Forgetlongequations,computer-geekgibberish,andinstallingbulkyprogramsthatslowdownyourcomputer.You'llbeamazedatallthethingsyoucanaccomplishjustbyloggingonandfollowingthesetrustydirections.Yougetthetoolsyouneedto:AnalyzealltypesofsequencesUsealltypesofdatabasesWorkwithDNAandproteinsequencesConductsimilaritysearchesBuildamultiplesequencealignmentEditandpublishalignmentsVisualizeprotein3-DstructuresConstructphylogenetictreesThisup-to-datesecondeditionincludesnewlycreatedandpopulardatabasesandInternetprogramsaswellasmultiplenewgenomes.Itprovidestipsforusingserversandplacestoseekresourcestofindoutaboutwhat'sgoingoninthebioinformaticsworld.BioinformaticsForDummieswillshowyouhowtogetthemostoutofyourPCandtherightWebtoolssoyou'llbesearchingdatabasesandanalyzingsequenceslikeapro!
作者简介
Jean-MichelClaverieisProfessorofMedicalBioinformaticsattheSchoolofMedicineoftheUniversitédelaMéditerranée,andaconsultantingenomicsandbioinformatics.HeisthefounderandcurrentheadoftheStructural&GenomicInformationLaboratory,locatedinMarseilles,asunnycityontheMediterraneancoastofFrance.Usingscienceasapretexttotravel,Jean-MichelhasheldpositionsinParis(France),Sherbrooke(PQ,Canada),theSalkInstitute(LaJolla,CA),thePasteurInstitute(Paris),Incytepharmaceutical(PaloAlto,CA);andtheNationalCenterforBiotechnologyInformation(Bethesda,MD).Hehasusedcomputersinbiologysincetheearlydays––hisPh.D.workinvolvedmodelingbiochemicalreactionsbyprogrammingan8KHoneywell516computerrightfromtheconsoleswitches!Althoughhehasnoclearrecollectionofit,hehasbeencreditedwithintroducingtheFrenchword"bioinformatique"inthelateeighties,beforeinvoluntarilycoiningthecatchy"bioinformatics"bymistranslatingitwhilegivingatalkinEnglish!Jean-Michel'scurrentresearchinterestsareinmicrobialandstructuralgenomics,andinthedevelopmentofbioinformaticmethodsforthepredictionofgenefunction.Heistheauthororcoauthorofmorethan150scientificpublications,andamemberofnumerousinternationalreviewpanelsandscientificcouncils.Inhissparetime,heenjoystherelaxedpaceoflifeinMarseilles,withhiswifeChantalandtheirtwosons,NicholasandRaphael.CedricNotredameisaresearcherattheFrenchNationalCentreforScientificResearch.CedrichasusedandabusedthefacilitiesofferedbysciencetowanderaroundEurope.AfteraPh.D.atEMBL(Heidelberg,Germany)andattheEuropeanBioinformaticsInstitute(Cambridge,UK)underthesupervisionofDesHiggins(yes,theClustalWguy),Cedricdidapost-docattheNationalInstituteofMedicalResearch(London,UK),inthelabofWillieTaylorandunderthesupervisionofJaapHeringa.Hethendidapost-docinLausanne(Switzerland)withPhillipBucher,andremainedinvolvedwiththeSwissInstituteofBioinformaticsforseveralyears.Havinghadhisshareofrain,snow,andwind,CedrichasfinallysettledinMarseilles,wherethesunandtheseaaresimplywarmerthananyotherplacehehaslivedin.Cedricdedicatesmostofhisresearchtothemultiplesequencealignmentproblemanditsmanyapplicationsinbiology.Hisfriendsclaimthathisentirelife(past,present,future)issomehowstuffedintotheT-Coffeemultiple-sequencealignmentpackage.WhenheisnotbusydismantlingT-Coffeeandbrewingnewsequences,Cedricenjoyslifeinthecompanyofhiswife,Marita.
