ClassicsinTotalSynthesisIII

作者 K. C. Nicolaou著Jason S. Chen著
出版社 Wiley-VCH
出版时间 2011年4月
ISBN 9783527329588
定价 1139.00

内容简介

Retaininghisexcellent,provenapproach,world-famouschemistandpassionateteacherK.C.NicolaouandhisstudentJasonS.Chencompileheretheimportantstrategiesandtoolsemployedtoconstructcomplexmolecules.Through42synthesesof25challengingnaturalproductstheyexplaintheykeystepsofthesyntheticpathway,highlightingthemajordevelopmentsforeasierunderstanding,andcontrastingthesetoothersyntheticmethods.Similartoitspredecessorsandcompletingatrilogy,thistextbookanalyzesthesynthesesinadidacticmanner,withseveralchaptersincludingmini-reviewsofkeymethodologies,andanemphasisonthehistory,mechanism,scope,andgeneralityofthereactions.Incontrasttothefirsttwovolumes,thisnewonefeaturesfull-colorfrontispieces.Awonderfultoolforlearningandteaching,andamust-haveforallcurrentandfutureorganic,medicinalandbiologicalchemists.Fromthereviews:“Thepresentvolume—andhopefullyfuturebooksofthisseries—offeranexcitingandoutstandingoverviewofthesubjectofnaturalproductstotalsynthesesinitscomplexityandvariety.ClassicsinTotalSynthesisIIIwillsurelyitselfbecomeaclassicintheliteratureonthestateoftheartofcontemporaryorganicsyntheticchemistry.“-AngewandteChemieInt.Ed.2011"...avolume,(...)whichanychemistwithaninterestinsyntheticorganicchemistrywillwishtoacquire."-JACS(onapreviousvolume)"...thissuperbbook(...)willbeanessentialpurchaseformanyorganicchemists."-Nature(onapreviousvolume)"...Oneofmyco-workersconfessedthatClassicsIwasthebookonhisbedsidetablewhilehepreparedhisthesisdefense.Isn'tthatthehighestdistinctionforamonograph?"-AngewandteChemie,2004(onapreviousvolume)

作者简介

K.C.NicolaouisProfessorofChemistryattheUniversityofCalifornia,SanDiegoandisChairmanoftheDepartmentofChemistryandholdstheSkaggsProfessorshipofChemicalBiologyandtheDarleneShileyChairinChemistryatTheScrippsResearchInsitute.HestudiedchemistryattheUniversityofLondon,andfinishedhisPh.D.in1972withProfessorsSondheimerandGarratt.AfterhispostdocsatColumbiaUniversitywithProfessorKatzandHarvardUniversitywithProfessorCorey,hejoinedtheUniversityofPennsylvania,beforeacceptingappointmentsattheUniversityofCaliforniainSanDiego.Hisimpactonchemistryflowsfromhisworksinchemicalsynthesisandchemicalbiologydescribedinover550publicationsand55patents,andhereceivednumereousawardsfromallovertheworld.Hisbook"ClassicsinTotalSynthesisIandII"arelong-andbestsellersaswellasundispensibleinviewofchemicaleducationinthestrategyoforganicsynthesis.JasonS.ChenreceivedhisABandAMdegreesin2001fromHarvardUniversity,whereheperformedresearchinthegroupofProfessorMatthewD.Shair.HethenjoinedEnantaPharmaceuticals(USA)asamedicinalchemiststudyingnovelcyclosporineanalogs.HejoinedK.C.Nicolaou'sgroupattheScrippsResearchInstitutein2003.In2008,hecompletedhisPh.D.onthetotalsynthesisandbiologicalevaluationofuncialamycin.HeisworkingcurrentlyasaresearchassociateinK.C.Nicolaouslaboratory.

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