SignallingNetworksinCellShapeandMotility

Thisbookfeaturescontributionsfromexpertsincellbiology,genetics,neurobiology,immunologyandstructuralbiology.Theunifyingelementisthattheyallstudyprocessesofcellshapechangeandmotility.Severalkeyquestionsinthisfieldofresearcharediscussed:Whataretheorganisingprinciplesbehindcellshapechange?Arethere‘masterswitches’presentineverycelltype?Howareextracellularsignalsinterpretedbythecellinordertoactivateintracellularmechanisms?Whatistheinfluenceoftheextracellularmatrixoncellmovementandinternalsignallingpathways?Howdopathogenssubvertcellularsystemsinordertostimulateorblocktheiruptake?Thebookaddressesalloftheseimportantquestions.Dataarepresentedonthekeyproteinsthatregulatecellshape:theGTPbindingproteinsoftheRhofamily.Therearealsoextensivediscussionsofthepotentialapplicationsofthedatatoclinicalproblems,particularlythatofcellmotilityincancer.